Cardio-protective functions

Dual inhibitors of COX and 5-LOX will not only suppress prostaglandins that contribute to acute inflammation conditions, but also address the accumulation of phagocytic leukotrienes that are directly associated with chronic inflammation symptoms. With the existence of COX-1 inhibition activities, dual inhibitors will also possess the cardio protective functions. Those characteristics suggest that there may be distinct advantages to dual inhibitors of COX and 5-LOX over selective COX-2 inhibitors and NSAIDs. This concept has been proved to be valid on in vivo models with synthetic drug candidates [105]. 

Dimethylsulfoxide (DMSO) is the antidote of choice for anthracycline and mitomycin C extravasations. It readily penetrates tissues and increases diffusion in the tissue area. In addition, DMSO is a free-radical scavenger that functions to block this principal mechanism of anthracycline- and mitomycin C-mediated tissue injury. DMSO generally is well tolerated but may cause some mild burning and redness. Dexrazoxane is a free-radical scavenger typically used for cardio-protection from anthracyclines. Promising results have been seen with large-volume extravasations and in a mouse model.38... 

---