4-Carboxy-5-amino triazoles

Reaction of ethyl 5-amino-3-methylthio-l//-pyrazol-4-carboxylate 267 with sodium nitrite in the presence of hydrochloric acid gives the diazo intermediate 268, which on treatment with active methylenic compounds such as ethyl a-chloroacetate or a-chloroacetylacetone affords the hydrazonyl chlorides 269 and 270, respectively, whose reaction with triethylamine in refluxing ethanol convert them into ethyl 4-hydro-2-methylthiopyrazolo[5,l-c]-[l,2,4]triazole-3,6-dicarboxylate 271 and ethyl 6-acetyl-4-hydro-2-methylthiopyrazolo[5,l-c][l,2,4]triazole-3-carboxy-late 272 (Scheme 23) <2001MI1>. 

Carboxy-l,3-diamino-2,4,6-trinitrobenzene 5-Nitro-2(3,5-diamino-2,4,6-trinitrophenol)-1,2,4-triazole 5-Nitroterazolecopper salt 5-Ureido-l,3-diamino-2,4,6-trinitrobenzene 7-Amino-4,6-dinitrobenzofuroxan 10-Chloro-5,10-dihydrophenarsazine Acetyltrinitro-cyclotetramethylene tetramine Acquinite... 

Furthermore, MCM-41, MCM-48, and SBA-15 silica materials have been lined/ functionalized with, for example, alkyl,104 105 amino or aminopropyl groups,106-120 diamine,121,122 triamine,122,123 ethylenediamine,124 imidazole,120,125-127 triazol,120 A-benzylidenebutan-1 -amine,128 malonamide,129 carboxy(late),108,112,114... 

Amino-6-nitro- XI/1, 196 Quinoxalin 2-Nitromethyl- E16d, 148 (H N02) lH-l,2,3-Triazol 4-Carboxy-l-phenyl- E8d, 360 (5-COOH 5-H)... 

Amino-5-hydroxy-1,2,3-triazole-4-carboxy-lic acid hydrazide or 1-Amino-4 hydrazido-carbon-5-hydroxytriazoie,(Called 1-Amino-4-hydrazidocarbon-5-oxytria2ol in Ref 2), HO-C-N(NHj) N, mw 158.13, N... 

Amino-a-vic-triazole-4(5)-carboxy lie Acid or 5(4)-Amino-IH-l,2,3-trio2ole-4(5)-carboxylic Acid,... 

Condensation of 2-amino-5-aryl-5//-thiazolo[4,3-6][I,2,4]oxadiazoles (93 X = 0) and -thia-diazoles (93 X = S) with formaldehyde and a-amino acids leads to 7-aryl-3-(carboxy-alkyl)thiazolo[3, 4 3,2][I,3,4]oxadiazoles (94 X = 0) and -thiadiazoles (94 X = S), respectively. Under the same reaction conditions 5-aryl-2-sulfonyl-l,5-dihydrothiazolo[3,4-Z)][l,2,4]triazoles (95) are converted into 7-aryl-3-(carboxyalkyl)thiazolo[3, 4 2,3][l,2,4]triazoles (96) (Equation (9)) <94MI 805-01 >. 

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