Carbonyldiimidazole copolymer

Degradable brush PHEMA-PDMAEMA-based copolymers were prepared by a combination of ATRP and click chemistty. Click chemistry introduced by Sharpless et al. is one of the most widely used approaches to prepare well-controlled macromolecules and biomolecules. " An azido-modified ATRP initiator was used to prepare PDMAEMA. PHEMA prepared by ATRP was modified with carbonyldiimidazole (CDI)-activated PDMAEMA. The click reaction between two polymers yielded brush polymers of varying molecular weights (Scheme 3.11). A brush copolymer of PDMAEMA of 50 kDa showed high p-galactosidase expression in Cos-7 cells, compared to analogues of other molecular weights. ... 

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