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Carbonyl compounds potassium hexamethyldisilazide

Base for a-Deprotonation of Carbonyl Compounds. Potassium hexamethyldisilazide, KN(TMS)2 (KHMDS) has been... [Pg.441]

Enolate hydroxylation (cf. 11, 108).2 Enolates of ketones or esters are oxidized by this oxaziridine to a-hydroxy carbonyl compounds. Yields are highly dependent on the base they are highest with potassium hexamethyldisilazide. Yields are generally higher than those obtained with the Vedejs reagent (MoOPH, 8, 207). [Pg.392]

A similar carbonyl addition with benzaldehyde derivatives having an ortho-allylic ether led to a benzopyranone when treated with potassium hexamethyldisilazide. ° These reactions are not successful when the alkene contains electron-withdrawing groups, such as halo or carbonyl groups. A free-radical initiator is required, usually peroxides or UV light. The mechanism is illustrated for aldehydes but is similar for the other compounds ... [Pg.1136]

See other pages where Carbonyl compounds potassium hexamethyldisilazide is mentioned: [Pg.322]    [Pg.322]    [Pg.259]    [Pg.373]    [Pg.461]   
See also in sourсe #XX -- [ Pg.317 ]



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Carbonyls hexamethyldisilazide

Hexamethyldisilazide

Hexamethyldisilazides

Potassium carbonyl compounds

Potassium compounds

Potassium hexamethyldisilazide

Potassium hexamethyldisilazides

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