Carbonic acid magnesium salt anhydrous

Synonyms carbonic acid, magnesium salt anhydrous (1 1) E504 magnesite. 

Lactose Magnesium carbonate hydroxide Magnesium chloride Magnesium hydroxide Magnesium sulfate anhydrous Magnesium sulfate heptahydrate D-Mannitol Meroxapol 105 Nickel Nitrogen Papain Poloxamer 183 Poloxamer 212 Poloxamer 215 Poloxamer 217 Poloxamer 231 Poloxamer 234 Poloxamer 235 Poloxamer 237 Poloxamer 238 Poloxamer 282 Poloxamer 284 Poloxamer 288 Poloxamer 331 Poloxamer 333 Poloxamer 334 Poloxamer 335 Poloxamer 338 Poloxamer 401 Poloxamer 402 Poloxamer 403 Poloxamer 407 Polymaleic acid Polymaleic acid sodium salt Potassium acid tartrate... 

An oven-dried 100 ml flask with a side arm dosed with a septum is fitted with a magnetic stirring bar and a reflux condenser connected to a mercury bubbler. The flask is cooled to room temperature under nitrogen, charged with 4.36 g (0.025 mol) of adipic acid monoethyl ester followed by 12.5 ml of anhydrous tetrahydrofuran, and cooled to —18° by immersion in an ice-salt bath. Then 10.5 ml of 2.39 m (or 25 ml of 1 m) solution of borane in tetrahydrofuran (0.025 mol) is slowly added dropwise over a period of 19 minutes. The resulting clear reaction mixture is stirred well and the ice-salt bath is allowed to warm slowly to room temperature over a 16-hour period. The mixture is hydrolyzed with 15 ml of water at 0°. The aqueous phase is treated with 6 g of potassium carbonate (to decrease the solubility of the alcohol-ester in water), the tetrahydrofuran layer is separated and the aqueous layer is extracted three times with a total of 150 ml of ether. The combined ether extracts are washed with 30 ml of a saturated solution of sodium chloride, dried over anhydrous magnesium sulfate, and evaporated in vacuo to give 3.5 g (88%) of a colorless liquid which on distillation yields 2.98 g (75%) of ethyl 6-hydroxyhexanoate, b.p. 79°/0.7 mm. 

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