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Carbon nucleophiles intra-intermolecular reactions

In the Claisen condensation mechanism, the sodium methoxide removes an acidic hydrogen from the carbon a to the carbonyl carbon, resulting in the formation of an enolate ester (Wiedermann et al., 1961). This reaction produces a carbanion, a powerful nucleophile. This nucleophile will attack carbonyl groups, forming a P-keto ester intermediate and a glycerylate. The glycerylate is now free to attack other carbonyl carbons and exchange esters intra- and intermolecularly. Once this carbanion is created, the same considerations as for the usual carbonyl carbon chemistry apply. [Pg.482]


See other pages where Carbon nucleophiles intra-intermolecular reactions is mentioned: [Pg.231]    [Pg.421]    [Pg.1780]    [Pg.110]    [Pg.1321]    [Pg.423]    [Pg.162]    [Pg.1321]    [Pg.80]    [Pg.93]    [Pg.358]    [Pg.110]    [Pg.80]    [Pg.177]    [Pg.764]    [Pg.791]    [Pg.145]    [Pg.325]    [Pg.402]    [Pg.229]   
See also in sourсe #XX -- [ Pg.1418 , Pg.1419 , Pg.1420 ]




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