Wittig reaction carbon-chain homologations

With this new approach in mind, the revised retrosynthetic analysis would utilize two different Wittig reactions to homologate the carbon side chains, providing ketoolefm (+)-16 (Scheme 13). Further disconnection revealed hydroxy aldehyde (+)-27 which could arise from a selective DIBALH reaction of lactone (+)-28. Applying Bringmann s method, lactone (+)-28 would be enantiomerically enriched via a kinetic resolution of a racemic lactone mixture. Racemic lactone ( )-28 could arise from a... 

Oxidative chain extension.- Reaci hydes and the Wittig reaction with .ul cordingly, three-carbon homologation o ably, the transformation is successful ii... 

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