Carbohydrates epichlorohydrin

Addition of an aqueous solution of PEG to a saturated aqueous solution of a-CD at room temperature did not lead to complex formation unless the average molecular weight of PEG exceeded 200 [46]. Moreover, carbohydrate polymers such as dextran and pullulan failed to precipitate complexes with PEG, and the same was true for amylose, glucose, methyl glucose, maltose, maltotriose, cyclodextrin derivatives, such as glucosyl-a-CD and maltosyl-a-CD, and water-soluble polymers of a-CD crosslinked by epichlorohydrin. These facts suggested to Harada et al. the direction for further research. 

Applications of PTCs in organic synthesis include polymer reactions, aromatic substitutions, dehydrohalogenations, oxidations, and alkylations of sugars and carbohydrates. PTCs can be used jointly with organometallic complexes as cocatalysts, bonded to polymeric matrices and used in asymmetric syntheses (34). Industrial applications have been in the manufacture of pharmaceuticals, pesticides, and other chemicals, including epichlorohydrin and benzotrichloride. 

Simkovic C., Hricovini, M., Soltes, L. et al. Preparation of water-soluble/insoluble derivatives of hyaluronic acid by cross-linking with epichlorohydrin in aqueous NaOH/NH40H solution. Carbohydrate Polymers. 2000, v. 41,9-14. 

Huang, R., Chen, G., Sun, M., and Gao, C. 2006. A novel composite nanofiltration (NF) membrane prepared from graft copolymer of trimethylaUyl ammonium chloride onto chitosan (GCTACC)/poly(acrylonitrile) (PAN) by epichlorohydrin cross-linking. Carbohydr. Res. 341 2777-2784. 

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