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Biotin-hydrazide also may be used to couple with carboxylate-containing molecules. Hydrazidcs can be coupled with carboxylic acid groups by using the carbodiimide reaction (Chapter 3, Section 1.1). The carbodiimide activates a carboxylate to an o-acylisourea intermediate. Biotin-hydrazide can react with this intermediate via nucleophilic addition to form a stable covalent bond. [Pg.526]

See other pages where Carbodiimides biotin-hydrazide is mentioned: [Pg.251] [Pg.251] [Pg.229] [Pg.735] [Pg.919] [Pg.609] [Pg.589]

See also in sourсe #XX -- [ Pg.390 ]

See also in sourсe #XX -- [ Pg.390 ]