Carbodiimide-Mediated Reactions of A-Acylamino Acids and Peptides

FIGURE 1.14 Carbodiimide-mediated reactions of At-acylamino acids and peptides. 

FMF Chen, NL Benoiton. Do acylamino acid and peptide anhydrides exist in K Blaha, P Malon, eds. Peptides 1982. Proceedings of the 17th European Peptide Symposium. Walter de Gruyter, Berlin, 1983, pp 67-70. 

FIGURE 1.15 Preformed symmetrical anhydrides of IV-alkoxycarbonylamino acids.13 The reaction is effected in dichloromethane. The N,N -dicyclohexylurea is removed by filtration. The symmetrical anhydride is not isolated. 

H Schiissler, H Zahn. Contribution on the course of reaction of carbobenzoxyamino acids with dicyclohexylcarbodimide. Chem Ber 95, 1076, 1962. 

F Weygand, P Huber, K Weiss. Peptide synthesis with symmetrical anhydrides I. Z Naturforsch 22B, 1084, 1967. 

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