Spironolactone Carbenoxolone

Gastrointestinal system Carbenoxolone Cimetidine Amiloride, spironolactone Antacids Inhibition of ulcer healing. Reduced absorption if taken simultaneously. 

Spironolactone inhibits the ulcer-healing action of carbenoxolone (SEDA-6, 317). 

Spironolactone abohshes the ulcer-heahng properties of carbenoxolone (24). 

Doll R, Langman MJ, Shawdon HH. Treatment of gastric ulcer with carbenoxolone antagonistic effect of spironolactone. Gut 1968 9(l) 42-5. 

Carbenoxolone causes fluid retention and raises blood pressure in some patients. This may be expected to oppose the effects of antihypertensive drugs. The potassium-depleting effects of carbenoxolone and diuretics such as the thiazides or loop diuretics can be additive. Spironolactone or amiloride can oppose the ulcer-healing effects of carbenoxolone. 

High dietary potassium has been linked to lower blood pressure, and dietary supplementation with moderate amounts of potassium has been found to lower blood pressure. Many drugs have effects in either raising or lowering potassium levels in the body. Levels are raised by digoxin, trimethoprim-sulfamethoxazole, ibuprofen, ACE inhibitors, angiotensin receptor blockers, spironolactone and heparin. Levels of potassium are lowered by diuretics, corticosteroids pseudoephedrine, some penicillins, carbenoxolone, caffeine and theophylline. 

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