Carbazoles nitrogen atoms functionalization

Another example of functionalization of carbazole nitrogen atoms was exhibited when Baran and co-workers demonstrated that carbazole and derivatives thereof were dimerized under electrochemical conditions. The aforementioned methodology enabled the concise and first synthesis of an N-N linked natural product—dixiamycin B (287) (14JA5571). 

With few exceptions, the reactions of functional groups separated by a chain of two or more saturated atoms from carbazole nitrogen show no deviation from their normal behavior. 

These include alkaloids and non-alkaloids that have phenolic functions in addition to a nitrogen atom. Even the alkaloids containing phenolic functions cannot be classified under one group. They may be phenyl alkyl amines, quinolines, isoquinolines, benzylisoquinolines [47-50], carbazole [51, 52] and others. However, they are included in this entry owing to their phenolic nature. Some of these compounds, like opium alkaloids, are of great medicinal importance. 

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