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Imipenem, carbapenem antibiotic syntheses

One of my favorite topics in process research is chemical lore, and we have all fallen victim to it. Years ago we were designing and developing the first practicable synthesis of imipenem, the first carbapenem antibiotic to reach the market.(3) As part of this synthesis lactone 1 (Scheme 1) was solvolyzed in benzyl alcohol, which afforded a 3 1 mixture of the desired benzyl ester and the... [Pg.4]

See other pages where Imipenem, carbapenem antibiotic syntheses is mentioned: [Pg.13] [Pg.303] [Pg.8] [Pg.1902] [Pg.8] [Pg.330] [Pg.1462] [Pg.5] [Pg.23] [Pg.303] [Pg.263]

See also in sourсe #XX -- [ Pg.3 , Pg.4 , Pg.7 , Pg.9 ]

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Antibiotics carbapenem

Carbapenem

Carbapenem antibiotic, imipenem

Carbapenem antibiotics synthesis

Carbapenem synthesis

Carbapenems imipenem

Carbapenems, synthesis

Imipenem

Imipenem antibiotic