Carbamazepine Acetylsalicylic acid

Figure 3.8 (a) Packing diagram of carbamazepine.formic acid solvate and (b) packing diagram of carbamazepine acetylsalicylic acid co-crystal... 

Sotalol, metoprolol, propranolol, carvedilol, nifedipine, captopril, cilazapril, milrinone, ticlopidine, acenocoumarol, furosemide, acetylsalicylic acid, salicylic acid, ibuprofen, naproxen, ketoprofen, diclofenac, paracetamol, dipyrone, mildronate, sildenafil, dexa-methasone, carbamazepine, terbinafine/urine UHPLC MS/MS Column Zorbax Rapid Resolution High Definition SB-C18 (50 x 2.1 mm, 1.8 pm) Mobile phase Solvent A 0.1 % HCOOH in water Solvent B MeOH (gradient elution) Detection MS/MS, ionization ESI Protein precipitation LOQ 0.05-0.60 ng/mL [71]... 

Cross reactivity At a concentration of 1 000 mg/1 in serum the following compounds increased the apparent value for a 15 mg/1 phenytoin control by < 20% acetaminophen, acetylsalicylic acid, amobarbital, barbital, butabarbi-tal, caffeine, carbamazepine, ethosuximide, fluphenazine, hexabarbital, p-hy-droxyphenobarbital, indomethacin, methylphenobarbital, meprobamate. 

Figure 18.13 Optimized chromatogram of a six-component mixture with acids and bases [reproduced with permission from Y. Hu and D.L. Massart, J. Chromatogr., 485, 311 (1989)]. Conditions column, 25cm x 4mm i.d. stationary phase, LiChrosorb RP18 5ixm mobile phase, 1 ml min methanol-phosphate buffer pH 3.0 (1 1) UV diode array detector. Peaks 1 = paracetamol 2 = acetylsalicylic acid 3 — caffeine 4 = benzocaine 5 = carbamazepine 6 = propyphenazone.

Acetaminophen Acetazolamide Acetylsalicylic acid Allopurinol P-Lactam antibiotics Benzodiazepines Brompheniramine Carbamazepine... 

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