Carbamates providing heterocyclic products

A number of studies have focused on the development and application of asymmetric versions of Pd-catalyzed allyUc alkylation reactions [72]. Trost has developed a class of ligands, including 94 and 9S, that provide excellent yields and enantioselectivities for many of these reactions. For example, treatment of aUylic acetate 92 with 1 mol% of allylpalladium chloride and 3 mol% of ligand 94 led to the formation of 93 in 97% yield and 91% ee (Eq. (1.41)) [73]. Asymmetric desymme-trization reactions of meso-bis-carbamates that provide heterocyclic products have also been described [74]. 

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