Captopril nephrotoxicity

Nephrotoxicity is caused by drugs that principally affect the renal hemodynamics of the patient depended on vasodilator prostaglandin biosynthesis or angiotensin converting enzyme (ACE) mediated vasoconstriction drugs causing nephrotoxicity include NSAIDs (fenprofen), ACE inhibitors (captopril, and cyclosporin). 

Endre ZH, Nicholls LG, Ratcliffe PJ, Ledingham JGG Prevention and reversal of mercuric chloride-induced increase in renal vascular resistance by captopril, in Nephrotoxicity Extrapolation from in vitro to in vivo and from animals to man., edited by Bach PH, LockEA, New York, Plenum, 1989, pp 103-106... 

GerkensJF, Smith AJ. Effect of captopril and theophylline treatment on cyclosporine-induced nephrotoxicity in rats.Transplanta-tion 1985 40 213-214. 

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