Captopril molecular structure

Fig. 7. A Zn21 -cyclen derivative (3) with coordinated captopril, and molecular structure of a Znn(cyclen)-N3 bound 1-MeT.

Captopril 678 and enalapril 679 are potent angiotensin converting enzyme (ACE) inhibitors used as antihypertensives. Molecular manipulation based on the enzyme model led to the discovery of some perspective bicyclic structures, for example, cilazapril 680 and compound 681, highly active antihypertensives in vivo. Compound 681 belongs to the most potent conformationally restricted ACE inhibitors and is often used as a model for molecular modeling studies <1996JA8231>. 

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