Clonidine Captopril

Acute administration of a short-acting oral drug (captopril, clonidine, or labetalol) followed by careful observation for several hours to ensure a gradual BP reduction is an option. 

Noninterfering albuterol, allopurinol, alprenolol, aspirin, atenolol, captopril, carbimazole, clonidine, coloxyl, danthron, diazepam, digoxin, doxepin, glibenclamide, hydralazine, in-domethacin, labetalol, metformin, methyldopa, metoprolol, mianserin, minoxidil, nifedipine, nitrazepam, oxazepam, oxprenolol, pindolol, prazosin, propranolol, senokot, theophylline, trifluoperazine... 

Noninterfering amiloride, acebutolol, acenocoumarol, acetaminophen, aspirin, allopuri-nol, ambroxol, amoxicillin, atenolol, bendroflumethiazide, benzbromarone, bezafibrate, biperiden, bisacodyl, bromazepam, butizide, captopril, cimetidine, ciprofloxacin, clobu-tinol, clonidine, cotinine, diazepam, diclofenac, digitoxin, digoxin, dihydrocodeine, dihy-droergotamine, diltiazem, doxepin, doxycycline, enalapril, erythromycin, fenoterol, furosemide, glibenclamide, heparin, h3qjoxanthine, ibuprofen, indomethacin, isosorbide... 

CENTRALLY ACTING ANTIHYPERTENSIVES ACE INHIBITORS Some evidence that when switching from clonidine to captopril, there may be a delayed onset of action of captopril Sudden cessation of clonidine causes rebound t BP, and this may be the reason for the delay in onset of captopril Monitor BP at least weekly until stable... 

Potentiation of the antihypertensive effect of clonidine by ACE inhibitors can be clinically useful. However, limited evidence suggests that the effects of captopril may be delayed when patients are switched from clonidine. Note that sudden withdrawal of clonidine may cause rebound hypertension. 

Acute hypotension occurred in a man receiving clonidine, captopril and furosemide who was premedicated with intramuscular midazolam 5 mg and anaesthetised with sufentanil 150 micrograms.This is consistent with another report of sudden hypotension during anaesthetic induction in 4 patients given high-dose sufentanil who had heen given lorazepam before induction. ... 

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