Nimodipine capsules

Nimotop Capsules (Nimodipine). Bayer Pharmaceuticals Corp. US Prescribing information, December 2005. 

Nimodipine Nimotop Capsule 30 mg 30-120 mg day Use as third-line agent for Blocks Ca+ influx through... 

Each liquid-filled capsule contains 30 mg nimodipine in a vehicle of glycerin, peppermint oil, purified water, and polyethylene glycol 400. The soft gelatin capsule shell... 

Nimodipine/ Nimotop /Bayer/ Vasodilator H H3C.. N, CH3 fl 11 OCH3 1 0 jx 0 jj—N02 60 mg (2 capsules) every 4 hours Soft gelatin capsule 30 mg Peppermint oil PEG 400 Water ... 

A mixture of peppermint oil and PEG 400 solubilizes 30 mg of nimodipine in Nimotop soft gelatin capsules. 

Some modified-release preparations of felodipine, nifedipine, and nisoldipine show markedly increased levels when given with food, particularly when high in fat. The bioavailability of lercanidipine is markedly increased by food, and it should therefore be given on an empty stomach. Manidipine should be given with food, as this improves its absorption. Food modestly decreases the rate and extent of absorption of nimodipine capsules. Food had no effect on the absorption of amlodipine, bepridil, diltiazem, isradipine, or verapamil in the studies cited. 

The US manufacturer notes that taking nimodipine capsules after a standard breakfast reduced the AUC by 38% and the peak level by 68% when compared with the fasted state in healthy subjects. ... 

In contrast, food modestly decreases the rate and extent of absorption of nimodipine capsules, and the US manufacturer says they should preferably be taken not less than one hour before, or two hours after, a meal. Food also modestly decreases the peak level of nicardipine, but the clinical relevance of this is uncertain. 

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