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Capsaicin receptor model

The pyrrolidine indole alkaloids (-n)-chimonanthine, weso-chimonanthine, and psychotridine also showed analgesic activity [120, 121], but the P. colorata quinoline alkaloids did not present positive results to the nociceptive tests, suggesting strong structure-activity relationship [115]. Capsaicin (the active component in pepper)-induced pain models suggest alkaloid action on opioid and glutamate receptors [119-121]. [Pg.136]

Pharmacologically, evodiamine has been widely studied as innovative antiobesity agent and was classified as a full TRPV-1 (transient receptor potential vanilloid-type 1) agonist. This receptor is a nonspecific ion chaimel and is activated by not only chemical compounds containing vanUlyl moiety but also heat (>45 °C) and acid (micromolar range) stimuli. It exhibited binding affinity similar to capsaicin in Chinese hamster ovary cell model. Despite similar in vitro and in vivo anti-obese activities between these compounds, evodiamine has not perceptible taste, including a peppery hot taste [80, 81]. [Pg.1451]

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See also in sourсe #XX -- [ Pg.91 ]



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