Capillary ESI interface

Figure 63 Schematic of a nanoscale capillary ESI interface. This specialized LC/MS interface, operating at flow rates from 20-500 nL/min and using 50 to 100 pm ID columns, typically provides low femtomole sensitivity. Fully automated sample handling and prearation procedures (i.e., desalting and preconcentration) combined with specialized devices for high separation and variable nL gradient flow rates provide unique capabilities for high-throughput analysis of proteins. (Courtesy of New Objective, Inc., Woburn, Ma., USA.)...

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