Cannabinoid receptors classification

Howlett, A.C. et al., International Union of Pharmacology. XXVII. Classification of cannabinoid receptors, Pharmacol. Rev., 54, 161, 2002. 

Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54 161-202... 

The ability of cannabinoids to cause vascular effects implies that the vasculature contains a molecular target. Evidence to date suggests that there may be vascular cannabinoid receptors, which may either fall into the classical CBj/CBj classification or represent a new subtype. As stated above, the biphasic hypotension in response to anandamide is absent in CBi receptor knockout mice (Ledent et al., 1999). This clearly points to the involvement of the CBj receptor. However, it should be noted that this does not conclusively identify the cannabinoid receptors as being on the vascular smooth muscle or associated with neuronal tissue. The sensitivity of vasorelaxant responses to CB receptor antagonists has been controversial, with some studies indicating that the responses are... 

---