Candida parapsilosis IFO

Hasegawa and co-workers [18] screened a number of microorganisms for the ability to degrade or deracemize selectively terminal 1,2-diols, useful intermediates for the synthesis of pharmacueticals, agrochemicals and liquid crystals. The yeast Candida parapsilosis IFO 0708 was the strain of choice for deracemization of the model substrate, pentan-l,2-diol 19. This biotransfor-... 

Two approaches were studied to obtain (R)-l,3-BDO. The first was based on an enzyme-catalyzed asymmetric reduction of 4-hydroxy-2-butanone, and the second was based on enantioselective oxidation of the undesirable (S)-l,3-BDO in the racemate. As a result of screening for yeasts, fungi, and bacteria, the enzymatic resolution of racemic 1,3-BDO by Candida parapsilosis IFO 1396, which showed differential rates of oxidation for two enantiomers, was found to be the most practical process to produce (R)-l,3-BDO with high enantiomeric excess and yield. 

Large-Scale Preparation of (R)-l, 3-BDO from the Racemate Using Candida parapsilosis IFO 1396... 

Cloning and Expression of a Gene Coding for a Secondary Alcohol Dehydrogenase from Candida parapsilosis IFO 1396 in Eschericha coli... 

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