Camphor oxidation

Rheinwald JG, AM Chakrabarty, C Gunsalus (1973) A transmissible plasmid controlling camphor oxidation in Pseudomonas putida. Proc Natl Acad Sci USA 70 885-889. 

Chapman PJ, G Meerman, JC Gnnsalns, R Srinivasan, KL Rinehart (1966) A new acyclic metabolite in camphor oxidation. J Amer Chem Soc 88 618-619. 

This enzyme [EC 1.14.15.1], also known as camphor 5-exo-methylene hydroxylase, and cytochrome P450-cam, catalyzes the reaction of (+)-camphor with putidare-doxin and dioxygen to generate (-F)-exo-5-hydroxy-camphor, oxidized putidaredoxin, and water. A heme-thiolate acts as a cofactor. The enzyme can also utilize ( )-camphor as a substrate, and l,2A-campholide will result in the formation of 5-exo-hydroxy-l,2-campholide. V. Ullrich W. Duppel (1975) The Enzymes, 3rd ed., 12, 253. 

Hedegaard, J., and I. C. Gunsalus, Mixed function oxidation. IV. An induced methylene hydroxylase in camphor oxidation , J. Biol. Chem., 240,4038-4043 (1965). 

Mercuric alkyl xanthates, 190, a-Mercuri camphor oxide, 200. 

Scheme 5.24 P450, -catalyzed camphor oxidation using bacterial GLD or yeast ADH for cofactor regeneration.

CAMPHOR c, 0 2-Camphonone, Synrihetk camphor, Gum camphor, Laurel camphor Oxidizers, chromk anhydride 150 0.6 3.5... 

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