Campbell’s degree of rate control

We now compute Campbell s degree of rate control in terms of the sensitivities for the forward and reverse rate constants. We compute the change in the overall rate, Sr, resulting from a change in kt by Ski and a change in k, by SkilKifiq to maintain the same equilibrium constant ... 

Therefore, Campbell s degree of rate control, XRCl, provides an excellent measure of the sensitivity of the overall reaction rate to the kinetic parameters for each step. The value of A"rc>( approaches zero as step i becomes quasi-equilibrated, and the value of 3lrC, becomes small as the preceding steps that produce the reaction intermediates for step i become irreversible. 

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