Calyceramide from Discodermia calyx

Calyceramides A-C, isolated from Discodermia calyx harvested in Japan, are inhibitors of neuraminidase, an enzyme on the surface of the influenza virus, which acts during the process of the spread of viral infection by degrading glycoconjuguates of sialic acid (N-acetylneura-minic acid). Neuraminidase inhibitors are rare, and sul-fated ceramides could be good models for study (Nakao et al., 2001). 

Three sulfated ceramides, calyceramides A-C (626-628) were isolated as inhibitors of neuraminidase from the marine sponge Discodermia calyx. Their structures were determined by spectroscopic and chemical methods [497],... 

Nakao Y, Takada K, Matsunaga S, Fusetani N. Calyceramides A-C neuraminidase inhibitory sulfated ceramides from the marine sponge Discodermia calyx. Tetrahedron 2001 57 3013-3017. 

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