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Calmodulin-binding peptides design

To obtain additional evidence in support of this hypothesis, three peptides were designed to be capable of forming a basic, amphiphilic a helix but to share little sequence homology with any natural calmodulin-binding peptide (Cox et al., 1985). The first two synthetic peptides, CBP1 and... [Pg.87]

Recently, a chameleon calcium reporter has been designed by R.Y. Tsien to sense calcium in cells by FRET. The structure of the system is based on a CEP separated from an YEP by the calmodulin calcium binding protein (CaM) and a calmodulin binding peptide (M13). If Ca ions are bound, CaM wraps around Ml 3 allowing high efficiency of excitation transfer from the donor CEP to the acceptor YEP (see Figure 9). The degree of FRET in chameleon is a sensitive ratiometric reporter (ratio 527/434 YPE/ CEP) of the calcium concentration in cells and in solution. The beauty of this approach is that the... [Pg.1393]

See other pages where Calmodulin-binding peptides design is mentioned: [Pg.68]    [Pg.44]    [Pg.228]    [Pg.319]    [Pg.95]    [Pg.147]    [Pg.90]    [Pg.193]    [Pg.303]    [Pg.1101]    [Pg.88]    [Pg.89]    [Pg.89]    [Pg.90]    [Pg.93]    [Pg.5542]    [Pg.225]    [Pg.188]    [Pg.5541]    [Pg.167]    [Pg.552]    [Pg.469]    [Pg.216]   
See also in sourсe #XX -- [ Pg.85 , Pg.86 , Pg.87 , Pg.88 , Pg.89 , Pg.90 , Pg.91 , Pg.92 , Pg.93 , Pg.94 , Pg.95 ]



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Calmodulin

Calmodulin binding

Calmodulin peptide binding

Calmodulins

Peptide binding

Peptide design

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