Calcium signaling overview

In this chapter, we provide a brief overview of voltage-gated calcium channel subtypes and function, with an emphasis on neuronal transmission. The structure and kinetics of calcium channels is an extensive field of study, and outstanding reviews have recently appeared [3,4]. This chapter is focused on the potential opportunities for small-molecule intervention in neuronal signaling via antagonism of voltage-gated calcium channel subtypes, with a brief review of the chemotypes that have been recently reported to modify channel function. 

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