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Calcium channels subunit interactions

The calcium channel p subunit is the only calcium channel subunit for which there is crystal structure information. The core of this subunit is homologous to membrane-associated guanylate kinases (MAGUKs), with conserved, interacting SH3 and guanylate kinase (GK) domains (Takahashi et al. 2004). Residues in the... [Pg.50]

Puri, T.S., Gerhardstein, B.L., Zhao, X.-L., Ladner, M.B. and Hosey, M.M. (1997) Differential effects of subunit interactions on protein kinase A- and C-mediated phosphorylation of L-type calcium channels. Biochemistry 36, 9605-9615. [Pg.281]

CPZ (9) also showed some inhibitory effects with respect to the calcium current produced by combined expression of aiE and (>3 subunits of voltage-sensitive calcium channels (VSCCs) [269]. The authors of this article suggested that this effect could be the result of either direct interaction of the drug with channel protein or indirect alteration of the properties of the lipid bilayer surrounding the VSCC molecules. [Pg.284]

Caulfield MP, Jones S, Vallis Y, Buckley NJ, Kim GD, Milligan G, Brown DA (1994) Muscarinic M-current inhibition via G alpha q/11 and alpha-adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neurones. J Physiol 477 Pt 3 415-22 Charvin N, L Eveque C, Walker D, Berton F, Raymond C, KataokaM, Shoji-Kasai Y, Takahashi M, De Waard M, Seagar MJ (1997) Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alphal A subunit of the P/Q-type calcium channel. Embo J 16 4591-6... [Pg.65]

Cooper CB, Amot MI, Feng ZP, Jarvis SE, Hamid J, Zamponi GW (2000) Cross-talk between G-protein and protein kinase C modulation of N-type calcium channels is dependent on the G-protein beta subunit isoform. J Biol Chem 275 40777-81 Coppola T, Magnin-Luthi S, Perret-Menoud V, Gattesco S, Schiavo G, Regazzi R (2001) Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin. J Biol Chem 276 32756-62... [Pg.66]

Opatowsky Y, Chomsky-Hecht O, Kang MG, Campbell KP, Hirsch JA (2003) The voltage-dependent calcium channel beta subunit contains two stable interacting domains. J Biol Chem 278 52323-32... [Pg.71]

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See also in sourсe #XX -- [ Pg.225 ]



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Calcium channels

Functional Interaction of the Calcium Channel Subunits

Interacting subunits

Subunit channeling

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