Calcitonin fragments synthesis

This technology has been successfully applied to the synthesis of various peptides (Leucine Enkephaline, Luteinising Hormone Releasing Hormone (L.H.R.H.), calcitonin fragments...). 

Smith DD, Li J, Wang Q, Murphy RF, Adrian TE, Elias Y, Bockman CS, Abel PW. Synthesis and biological activity of C-terminally truncated fragments of human-a-calcitonin gene-related peptide. J. Med. Chem. 1993 36 2536-2541. 

We present here the synthesis of fragments of the salmon calcitonin. 

The protected (S - S) (l-10) salmon calcitonin has been successfully coupled on a (ll-32) protected fragment grafted on a polystyrene resin. After final HF deprotection, the salmon calcitonin has been obtained with a better yield than stepwise synthesis on a polystyrene resin. A gain of 50 % of final salmon calcitonin is obtained using this procedure. 

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