Reducing agent cadmium-based

In order to accelerate the slow metalation, several methods have been proposed (1) use of substitution reaction of cadmium(II) or mercuty(II) porphyrin, (2) use of N-substituted porphyrins at the pyrrole nitrogen, (3) addition of aromatic heterocyclic bases such as pyridine and imidazole, (4) introduction of functional groups to bind metal ions in the vicini of the porphyrin nucleus (e. g. tetracarboxylic add "picket-fence" porphyrins) and (5) use of reducing agents such as hydroxylamine and ascorbic add in copperfll) incorporation. 

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