Caco cDNA expression

The abundant expression of a variety of transporters in Caco-2 cells also makes it attractive to apply functional genomics tools, such as cDNA arrays in order to map the expression [31] and relative abundance of these transporters [32], Also, genomic mapping of surface receptors on Caco-2 cells can be performed to study receptor-mediated endocytosis and other endocytotic pathways for larger molecules in enterocytes [33-36]. 

M., Development of Caco-2 cells expressing high levels of CDNA-derived cytochrome P450 3A4, Pharm. Res. 1996, 36, 1635-1641. 

Crespi CL, Penman BW, Hu M. Development of caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4. Pharmaceut Res 1996 13 1635-1641. 

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