C-Pentosidine

Plasma levels of creatine as well as of pentosidine increase in diabetic nephropathy, which leads to the possibility of creatine replacing arginine in the formation of pentosidine.376 Accordingly, lysine was incubated at 60 °C for 48 h with ribose and creatine, when on HPLC a novel fluorescent peak was detected. It reacted with an anti-pentosidine antibody and was identified by NMR and FAB-MS as C-pentosidine. 

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