C—H Bond Insertion by Ir Carbenoids

With regard to 1,4-eyelohexadiene (Table 1.8), all these above groups realized the intermoleeular C—H bond insertion reaction with the Ir-carbenoids derived from a-diazo esters 88 to achieve the corresponding adducts 89 in excellent yields and enantioselectivity. It is worth noting that, in Katsuki s work, the methyl a-diazopropionate (88, R = Me) was recognized as a feasible metallo-carbene precursor in this reaction. Historically, intermolecular reactions with 

Musaev, Davies and Blakey [R,R)-C6 (0.5 mol%) 4 A MS, neat, room temperature Aryl 13 examples Up to 99% yield, and 99% ee 

With respect to THF (Table 1.9), both the Katsuki group and the Che group accomplished the intermolecular C—H bond insertion reactions by utilizing their own chiral Ir complexes to afford the corresponding 2-substituted tetrahydrofuran 90 with satisfactory yields and ee. Similarly, the methyl a-diazopropionate (88, = Me) was also a suitable carbene precursor in this 

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