Butylhydroxytoluene

The vitamins, Cremophor EL, butylhydroxytoluene and benzyl alcohol are mixed together at around 60 °C, and water at 60 °C is slowly incorporated with vigorous stirring. 

Mix the vitamins, Solutol HS 15, butylhydroxytoluene and benzyl alcohol at approx. 60 °C, and then add the water (60 °C) slowly and with vigorous stirring. - After the ampoules have been heat-sterilized, they should be shaken for a short time, while they are still hot, to eliminate any separation of the phases that may have occurred. Sterilization can also be performed by membrane filtration under pressure. 

Heat the mixture of the vitamins with butylhydroxytoluene and Solutol HS 15 to about 65 °C. Heat the solution of the preservative in water to the same temperature and add it slowly to the well stirred vitamin mixture. 

Dissolve butylhydroxytoluene in the warm vitamin A, add Cremophor and mix with the molten macrogols. 

When 2 equiv (relative to catalyst) of 2,6-di-terf-butylhydroxytoluene (BHT, a radical reaction inhibitor) was added to the reaction, the yield of the reaction decreased by half. A radical trap experiment using cyclohexane was carried out in CCI4 as well, and together with 40% amination product, 12% of chlorocyclohexane was also detected. This result also suggests that a radical pathway is operative. When a 1 2.3 mixture of cis- and trans-2 pentene was reacted with PhI=NTs (Scheme 6.7), a 1 1.5 cis trans aziridine product was isolated, which suggests the mechanism may... 

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