Butanoic acid biosynthesis

We can descnbe the major elements of fatty acid biosynthesis by considering the for mation of butanoic acid from two molecules of acetyl coenzyme A The machinery responsible for accomplishing this conversion is a complex of enzymes known as fatty acid synthetase Certain portions of this complex referred to as acyl carrier protein (ACP), bear a side chain that is structurally similar to coenzyme A An important early step m fatty acid biosynthesis is the transfer of the acetyl group from a molecule of acetyl coenzyme A to the sulfhydryl group of acyl carrier protein... 

Sandanayaka V, Mamat B, Mishra RK et al (2010) Discovery of 4-[(2S)-2- [4-(4-chloro-phenoxy)phenoxy]methyl -l-pyrrolidinyl]butanoic acid (DG-051) as anovel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J Med Chem 53 573-585... 

Karanewsky DS, Badia MC, Ciosek CP, et al. Phosphorns-containing inhibitors of HMG-CoA reductase. I. 4-[(2-Arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids a new class of cell-selective inhibitors of cholesterol biosynthesis. Journal of Medicinal Chemistry 33 11), 2952, 1990. 

Stirling IR, Freer IKA, Robins DJ (1997) Pyrrolizidine alkaloid biosynthesis. Incorporation of 2-amino-butanoic acid labeled with C or H into the necic acid portion of rosmarinine and senecionine. J Chem Soc, Perkin Trans I 677-680... 

Ethyl bromide, H NMR spectrum, 503—504 Ethyl butanoate, Claisen condensation of, 851 Ethyl chloride, 48, 156. See also Chloroethane Ethyl cinnamate, 788 Ethyl cyanoacetate, 857 Ethylene, 168. See also Ethene acidity of, 343, 345, 552 biosynthesis of, 168 bond dissociation energies in, 343 bonding in, 14, 38-40, 47, 54, 170-171,... 

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