4 Hydroxy-1-butanesulfonic acid

Hydroxy- 1-butanesulfonic acid sultone has been made through the chlorosulfonation of 1-chlorobutane,3 from 4-chlorobutyl acetate 2 4 which is prepared through the reaction of tetrahydrofuran and acetyl chloride,2 from 4-chlorobutanol,4 and from bis-4-chlorobutyl ether.2 Both 4-chlorobutanol and bis-4-chlorobutyl ether can be prepared from tetrahydrofuran.6... 

Chlorobutane gives 1- and 4-chloro-2-butanesulfonyl chloride and 4-chloro-l-butanesulfonyl chloride,204 hydrolysis of which affords the corresponding sulfonic acids 4-chloro-2- and -1-butanesulfonic acid lose hydrogen chloride when heated, passing into sultones205 (internal anhydrides of hydroxy sulfonic acids). 

Fig. 8-100. Gradient elution of catecholamines with amperometric detection. — Separator column Zorbax ODS eluent (A) 0.005 mol/L triethylamine / methanol, (B) 0.07 mol/L KH2P04 + 0.005 mol/L triethylamine + 0.001 mol/L sodium butanesulfonate (pH 3) gradient linear, 5% A in 20 min to 56% A flow rate 1 mL/min detection amperometry at a GC working electrode oxidation potential +0.8 V injection volume 50 pL solute concentrations 4 ppm each of norepinephrine (1), epinephrine (2), 3,4-dihydroxybenzyl-amine (3), dopamine (4), seratonine (5), 5-hydroxy-3-indolylacetic acid (6), and homovanillic acid (7).

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