Butane 2,3-dimethyl-2,3-diphenyl

AI3-23740 Benzene, 1, T-(1,1,2,2-tetramethyl-1,2-ethanediyl)bis-Bibenzyl, a,a,a, a -tetramethyl- Butane, 2,3-dimethyl-2,3-diphenyl-a,a -Dicumyl 2,3-Dimethyl-2,3-diphenylbutane EINECS 217-568-2 NSC 34859 Perkadox 301,1 -(1,1,2,2-Tetramethylethylene)di-benzene. Akzo Chemie. 

Aus Stilben wird mit tert.-Butylchlorid bei -2,3 V ein 3 2-Gemisch aus 3,3-Dimethyl-1,2-diphenyl-butan und 2-Phenyl-1-(4-tert.-butyl-phenyl)-dthan5 erhalten. 

R1 = R2 = CH3 2,3-Pyrrolidino-2,3-dimethyl-butan R1 = H R2 = C6Hs 2,3-Pyrrolidino-2,3-diphenyl-butan... 

The nature of the aromatic substituents is apparently not critical for SSRI activity, as indicated by the structure of duloxetine (23-5), where one ring is replaced by thiophene and the other by naphthalene. The synthesis starts as above by the formation of the Mannich base (23-1) from 1-acetyl thiophene with formaldehyde and dimethyl-amine. Treatment of that intermediate with the complex from lithium aluminum hydride and the 2R,3S entantiomer of dimethylamino-l,2-diphenyl-3-methyl-butane-2-ol gives the S isomer (23-2) in high enantiomeric excess. Treatment of the aUcoxide from (23-2) and sodium hydride with 1-fluoronaphthalene leads to the displacement of halogen and thus the formation of ether (23-2). The surplus methyl group is then removed by yet another variant of the von Braun reaction that avoids the use of a base for saponifying the intermediate urethane. Thus, reaction of (23-3) with trichloroethyl formate leads to the A -demethylated chlorinated urethane (23-4). Treatment of that intermediate with zinc leads to a loss of the carbamate and the formation of the free secondary amine duloxetine (23-5) [23]. 

Nickel, dichloro [ethylenebis(dimethyl-phosphine)], 58, 133 Nickel, dichloro[ethj lenebis(diphenyl-phosphine)], 58,133 [Ni (-)-diop Cl2 ], (-)-diop=2,3-0-iso-propylidene-2,3-dihydroxy-l,4-bis(di-phenylphosphino)butane, 58, 133 Nickel, dichloro [ trimethylenebis(diphenyl-phosphine)], 58,133 NITRILES, alkylation of, 55, 91 NITRILES FROM KETONES, 58, 101 NITRILES, a vinyl, 55, 99, 101 p-Nitrobenzenesulfonyl cyanide, 57, 89 p-Nitrobenzyl alcohol, 57, 72 p-NITROBENZYL FLUORIDE, 57, 72 Nitro compounds, 56, 36 Nitronates, 56, 36... 

Attempted synthesis of the bis(2//-azirine) system from the 2,3-dimethyl-1,4-diphenyl-1,4-butane-dione bis(hydrazonium) salt under basic conditions gives 3,4-dimethyl-2,5-diphenylpyrrole in 89% yield (equation 66). ° ... 

Im Falle der Thermolyse (100°) iiberlagern sich heterolytische Spaltungsprozesse, wie aus den auf-tretenden Produkten zu entnehmen ist tert.-Butanol (17% d.Th.), Aceton, dessenDimethylaoetal (20% d.Th.), Methyl-isopropenyl-Sther (40% d.Th.), 2,3-Dimethyl-2,3-diphenyl-butan (20% d.Th.) und Succinimid (99% d.Th.). 

In other examples, biphotonic ionization of 2,3-dimethyl-2,3-diphenyl-butane (bicumene) in TFE gives the bicumene radical cation which undergoes carbon-carbon fragmentation to yield the cumyl cation and cumyl radical [87]. Photoinduced electron transfer from 2,2-dialkyldioxolanes to tetra-cyanoanthracene gives radical cations which fragment to yield dialkoxy carbocations and alkyl radicals [88]. Benzyl acetals were subjected to two-pho-... 

Dimethyl-2,5-di(tcrt-butylperoxy)-3-butane), 152 2,9-Dimethyl-4,7-diphenyl-l,10-phenanthroline, 34 7/,Ar-Drmethylformamide, 10, 162, 242, 453, 492... 

Diphenyl-3-methylbutane-l,2-diol, A"15.4 2-Methyl-3,4-diphenyl-butane-1,3-diol, A"44.7 4,4-Dimethyl-3-(l-naphthyl)butyric acid, A"45.14... 

Dimethyl-2,3-diphenyl butane Flakes, technically pure... 

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