Butadiene-1,3-diepoxide

Exposure studies have been made using mice and rats (257). These experiments have demonstrated species differences in butadiene toxicity and carcinogenicity. Butadiene was found to be a potent carcinogen in the mouse, but only a weak carcinogen in the rat. The interpretations have focused on differences in toxification rates and detoxification metaboHsms as causative factors (257). The metaboHsm is beHeved to proceed through intermediates involving butadiene monoepoxide and butadiene diepoxide (257). A similar mechanism has been proposed for its biodegradation pathway (258). [Pg.349]

Dg]-butadiene monoepoxide, 8, has been synthesized2 by treating the water solution (pH 5.5) of magnesium monoperoxyphthalate hexahydrate at room temperature with [Dg]-1,3-butadiene at 1 atmosphere in 94% yield after 50 min reaction time. Under these conditions less than 1% of butadiene diepoxide has been formed as determined by GC/MS. The concentration of the [Dg]-butadiene monoepoxide in the aqueous reaction mixture at various reaction times has been determined by selective ion monitoring of ions with mjz... [Pg.777]

Butadiene diepoxide, d546 Butanal, b612 1-Butanamine, b509... [Pg.127]

Bechtold, W.E., Strunk, M.R., Thomton-Maiming, J.R. Henderson. R.F. (1995) Analysis of butadiene, butadiene monoxide, and butadiene diepoxide in blood by gas chromatography/ gas chromatography/mass spectroscopy. Chem. Res. Toxicol., 8, 182—187... [Pg.204]

Thornton-Manning, J.R., Dahl, A.R., Beehtold, W.E., Griffith, W.C., Jr Henderson, R.F. (1995a) Disposition of butadiene monoepoxide and butadiene diepoxide in various tissues of rats andmiee following a low-level inhalation exposure to 1,3-butadiene. Carcinogenesis, 16, 1723-1731... [Pg.222]

The preparation of 4,5-diamine 1,2 dithiane, (II), from butadiene diepoxide is described and reviewed (2). [Pg.43]

SYNS BIOXIRANE 2,2 -BIOXIRANE BUTADIEN DIOXYD (GERMAN) BUTADIENE DIEPOXIDE 1,3-BUTADIENE DIEPOXIDE BUTADIENE DIOXIDE BUTANE DIEPOXIDE DEB DIEPOXYBUTANE 2,4-DIEPOXYBUTANE 1,2 3,4-DIEPOXYBUTANE DIOXYBUTADIENE ENT 26,592 ERYTHRITOL ANHYDRIDE RCRA WASTE NUMBER U085... [Pg.171]

BUTADIENE see BOP500 BUTA-1,3-DIENE see BOP500 a-Y-BUTADlENE see BOP500 BUTADIENE DIEPOXIDE see BGA750... [Pg.1552]

Substrates GSTTl-1—Dichlowmethane, ethylene dibromide, butadiene diepoxide, eumene hydroperoxide (moderate-high), l,2-epoxy-3 (4-nitrophenoxy-propane, ethylene oxide, methyl bromide, methylene chloride, 4-nitrobenzyl chloride, 4-nitrophenethylbromide, phenethylisothiocyanate. [Pg.81]

Alternative Names/Abbreviations 2,2 -Bioxirane, 1,1 -bi(ethylene oxide), butadiene diepoxide, butadiene dioxide, 2,4-diepoxy butane, dioxybutadiene... [Pg.226]

Ring-opening by cyanide anion in an alkaline solution of me o-butadiene diepoxide (387) evidently produced the expected we5o-l,4-dicyano-2,3-... [Pg.66]

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