Buspirone hydrochloride

Common Name Buspirone hydrochloride Structural Formula ... 

From the predictive category, we bring some examples of the application of the UNIFAC model. In one study, this model has been used to predict the solubility of naphtalene, anthracene, and phenanthrene in various solvents and their mixtures [8], They showed the applicability of the UNIFAC model in prediction of the phase behavior of solutes in solvents. There have been efforts to make the UNIFAC model more robust and powerful in the prediction of phase behaviors [14], In one study, the solubility of buspirone-hydrochloride in isopropyl alcohol was measured and evaluated by the modified UNIFAC model [15]. It was concluded that for highly soluble pharmaceutics, the modified form of the UNIFAC model was not suitable. In another study, the solubility of some chemical species in water and some organic solvents was predicted by the UNIFAC model [16]. For some unknown functional groups, they used other known groups which had chemical structures that were similar to unknown ones. 

M. Sheikhzadeh, S. Rohani, M. Taffish, S. Murad. Solubility analysis of buspirone hydrochloride polymorphs Measurements and prediction. Int. J. Pharm. 338 (2007) 55-63. 

Molecular formula CziHaiNsOz Molecular weight 385.5 CAS Registry No. 36505-84-7 (buspirone), 33386-08-2 (buspirone hydrochloride)... 

The mechanism of action of buspirone hydrochloride will be discussed as under ... 

Meidan, V.M., Al-Khalili, M., and Michniak, B.B. (2003). Enhanced iontophoretic delivery of buspirone hydrochloride across human skin using chemical enhancers, Int. J. Pharm., 264 73-83. 

Buspar (Buspirone hydrochloride). Bristol-Myers Pharmaceuticals. UK Summary of product characteristics, March 2007. 

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