Buspirone generalised anxiety disorder

Bond Al, Wingrove 1, Valerie CH, Lader MH. Treatment of generalised anxiety disorder with a short course of psychological therapy, combined with buspirone or placebo. 1 Affect Disord 2002 72 267-271. 

Buspirone may be used in generalised anxiety disorder as an alternative to a benzodiazepine. 

I 5-HTia partial agonists (e.g. buspirone) can decrease anxiety in generalised anxiety disorder (GAD) but are not effeetive in panie disorder. 

Buspirone is available as the hydrochloride salt (5 and 10 mg tablets) and is often considered to be useful for generalised anxiety disorder (GAD). Anxiolysis does not coincide with benzodiazepine-like sedation. The remaining derivatives are currently not available in most countries although tandospirone appears to he approved in Japan. The development of ipsapirone has heen discontinued and approval for gepirone for the treatment in depression is still being sought. 

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