Ticlopidine Bupropion

B6 Artemisinin, bupropion, cyclophosphamide, efavirenz, ifosfamide, ketamine, S-mephobarbital, S-mephenytoin (/V-demethylation to nirvanol), methadone, nevirapine, propofol, selegiline, sertraline, ticlopidine Phenobarbital, cyclophosphamide Ticlopidine, clopidogrel... 

Turpeinen M, Tolonen A, Uusitalo J, et al. Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation. Cbn Pharmacol Ther 2005 77 553-559. 

The display shown on Figure 2 has an alphabetical list of four precipitants (clopidogrel, erythromycin, ticlopidine, and levofloxacin) that have been evaluated with the substrates bupropion and efavirenz and which have shown more than 20% effect in in vivo inhibition. Each precipitant (inhibitor) in the list has its own folder containing more detailed information ... 

CYP2B6 <5 1-2 Bupropion Carbamazepi ne Cyclophosphamide Selegiline Flunitrazepam Meperidine Bupropion Selegiline Ethinylestradiol Phencyclidine Tamoxifen Ticlopidine Clotrimazole Carbamazepine Phenobarbital Phenytoin Pioglitazone Rifampin Troglitazone Valproic acid Ritonavir... 

B6 (iS)Mephenytoin Af-demethylation 7-Ethoxy-4-trifluoromethylcoumarin 0-deethylation" Bupropion hydroxylation Phenobarbital 2- Isopropenyl-2-methyladamantane 3- Isopropenyl-3-methyldiadamantane Triethylenethiophosphoramide" Ticlopidine Clopidogrel 5-Mephenytoin "... 

Clopidogrel and ticlopidine appear to inhibit the metabolism of bupropion. Dosage adjustments may be necessary. 

A study in healthy subjects given ticlopidine 250 mg twice daily for 4 days found that the AUC of a single 150-mg dose of bupropion was increased by 85% and the AUC of its active metabolite, hydroxybupropion was reduced by 84%. ... 

The reduction in bupropion hydroxylation is due to inhibition of its cytochrome P450 isoenzyme CYP2B6-mediated metabolism by elopidogrel or ticlopidine. ... 

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