Buildings hazard analysis, impact assessment

The instability of cyclopentadiene also required detailed study. Under adiabatic conditions, cyclopentadiene can spontaneously dimerize exothermically and thus should be stored cold for only short duration, especially on kilogram scales (Scheme 3). The impact of container size, volume, temperature, and solvent dilution on storage conditions was carefully studied to assess the potential of a runaway reaction. The published results of this analysis clearly show that hazards increase significantly as the volume of stored cyclopentadiene increases.35 These generation and storage issues of a simple yet key building block threatened the earliest step in the benzazepine sequence. 

---