Budesonide Grapefruit juice

Grapefruit juice increases plasma levels of methylprednisolone and is predicted to increase plasma levels of rectal budesonide. Grapefruit juice does not affect the pharmacokinetics of prednisone or prednisolone. 

Budesonide, Oral (Entocort EC) [Anti-inflammatory> Corticosteroid] Uses Mild-mod Crohn Dz Action Steroid, anti-inflammatory Dose Adults. Initial, 9 mg PO qAM to 8 wk max maint 6 mg PO qAM taper by 3 mo avoid grapefruit juice Contra Active TB and fungal Infxn Caution [C, /-] DM, glaucoma, cataracts, HTN, CHF Disp Caps SE HA, cough, hoarseness, Candida Infxn, epistaxis Interactions T Effects W/ erythromycin, indinavir, itraconazole, ketoconazole, ritonavir, grapefruit EMS Monitor ECG and BP for signs of electrolyte disturbances and hypovolemia OD Acute OD unlikely to cause a problem, chronic OD can reduce natural production of certain steroids symptomatic and supportive... 

One of the manufaeturers ofreetal budesonide predict that grapefruit juice will increase budesonide levels and therefore advise that concurrent use should be avoided. Even though budesonide plasma levels are higher after... 

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