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Bruceantin 4 ,5 -epoxide

Brucein-C (76), bruceantin-4, 5 -epoxide, and bruceantin-5 -ol were obtained as metabolites by incubation of bruceantin (1) in Streptomyces griceus [1]. This result revealed that the quassinoid side chain is biologically unstable. To overcome the instability, the side chain of... [Pg.308]

Studies of microbial transformations of bruceantin (53) led to the isolation of new analogs of this antitumor quassinoid (70). Thus, Streptomyces griseus (ATCC 10137) totally metabolized bruceantin (53) within 19 h, and a preparative scale incubation using bruceantin provided brucein C (51), bruceantin-4, 5 -epoxide and bruceantin-5 -ol. None of the metabolites were as active as bruceantin in the P388 test system (70). [Pg.233]

See other pages where Bruceantin 4 ,5 -epoxide is mentioned: [Pg.796]   
See also in sourсe #XX -- [ Pg.7 , Pg.388 ]

See also in sourсe #XX -- [ Pg.7 , Pg.388 ]



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