Bronsted acid catalyzed Friedel Crafts type reaction

In 2004 Terada and his group revealed that 2 methoxy furan (45) that can be considered as a vinylketene 0,0 acetal was sufficiently nucleophilic to engage Boc imines 44 in Bronsted acid catalyzed Friedel Crafts type reaction to furnish y aminoalkyl substituted furans 46 in excellent yields and up to 97% ee (Table 5.9) [ 16]. As already explained, phosphoric add 47 protonates the imine, thus generating a chiral contact ion pair the anionic counterion of which controls the enantioselectivity of the C C bond forming event. Although typically 2 mol% ofthe Bronsted acid were... 

This work incorporates all acid-catalyzed Friedel-Crafts-like acylation reactions. Thus, classic Lewis and Bronsted acid types are considered together with more innovative and advanced multicomponent superacid catalysts, ranging from rare earth triflates or triflimides and their... 

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