2-Bromomethyl-3,5,6-trimethylpyrazine

Note Hydrolysis may be done directly or via an acetoxy intermediate, often unisolated. The kinetics for hydrolysis of 2-bromomethyl-3,5,6-trimethylpyrazine have been investigated within the range pH 1 -11.1266... 

Bromomethyl-3,5,6-trimethylpyrazine 2-Bromo-5-morpholinopyrazine 4-oxide 2-Bromo-5-nitropyrazine... 

Deuterolysis of 3-chloro-2-chloromethyl-5-methoxypyrazine over 5% palladium on alumina in the presence of sodium isopropoxide in 2-propanol afforded 3-deutero-2-monodeuteromethyl-5-methoxypyrazine (687) and methylation of the bromomagnesium derivative from 2-bromomethyl-3,5,6-trimethylpyrazine with methyl sulfate or methyl iodide gave 2-ethyl-3,5,6-trimethylpyrazine (330). 

Chloromethylpyrazine (250) gave 2-(isothiouroniomethyl)pyrazine chloride (251) [S=C(NH2)2, MeOH, 1 h crude solid), and thence 2-(mercap-tomethyl)pyrazine (252) (1.3 M NaOH, reflux, N2, 1 h >20% overall) 674 2-bromomethyl- gave 2-mercaptomethyl-3,5,6-trimethylpyrazine (85%) in a similar way.1551... 

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