Bromolysergic acid diethylamide

Burris KD, Sanders-Bush E. (1992). Unsurmountable antagonism of brain 5-hydroxytryptamine2 receptors by (-i-)-lysergic acid diethylamide and bromolysergic acid diethylamide. Mol Pharm. 42(5) 826-30. 

Bromination of LSD 25 yields 2-bromolysergic acid diethylamide which exerts practically no psychotomimetic effect (Fig. 8a) the central excitation syndrome is reduced, whereas the antiserotonin effect remains intact, but the effect on smooth muscle is practically absent. This compound is almost as potent as LSD 25 in antagonizing serotonin but does not elicit hallucinogenic effects. 

In the rat, which is relatively insensitive to histamine, and possibly also in the mouse, 5-hydroxytryptamine (serotonin) may be an important factor in the production of vascular permeability " . Thus, inflammatory oedema in these species may often be prevented by the administration of serotonin inhibitors such as bromolysergic acid diethylamide . It is generally accepted, however, that histamine and 5-hydroxytryptamine cannot account for all the manifestations of vascular permeability in inflammation. Attention has been focused on possible mediators of higher molecular weight, especially peptides and proteins. 

Ergot alkaloids and derivatives Ergotamine Lysergic acid diethylamide (LSD) 2-Bromolysergic acid amide (BOL) 1-3 mg/day, 0.25-0.5 mg SC/IM... 

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