Domperidone Bromocriptine

Another cardiac response to catecholamine release is Increased vulnerability to ventricular fibrillation. Recent studies (13) have shown that bromocriptine produced an increase of 50% in the ventricular fibrillation threshold In anesthetized dogs, and that pretreatment with the peripheral D-2 dopamine antagonist domperidone abolished this effect. This suggests that adrenergic induced cardiac arrhythmia may be inhibited by peripheral presynaptic dopamine agonists. 

Domperidone and metoclopramide would be expected to reduce the prolactin-lowering effect of bromocriptine. Metoclopramide, but not domperidone, would be expected to reduce the effect of any dopamine agonist. 

Josamycin. An elderly man with Parkinson s disease, well-controlled for 10 months with daily levodopa/benserazide, bromocriptine 70 mg and domperidone, was additionally given josamycin 2 g daily for a respiratory infection. Shortly after the first dose he became drowsy with visual hallucinations, and began to show involuntary movements of his limbs, similar... 

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