2-Bromo-3-methylpyrazine

Bromo-5-methyl-2-pyrazinamine 3-Bromo-5-methyl-2-pyrazinamine 4-oxide 2-Bromo-3-methylpyrazine 2-Bromomethylpyrazine 1,4-dioxide... 

Bromo-3,5,6-trichloropy razi ne 2-Bromo-3,5,6-trifluoropyrazine 2-Bromo-3,5,6-trimethylpyrazine 2-Bromo-3,5,6-triphenylpyrazine 2- (But-1 -enyl)-5,6-dimethylpyrazine 2-(But-2-enyl)-5,6-dimethylpyrazine 2- (But-1 -enyl)-5-methyl-3-propylpyrazine 2- (But-1 -enyl)-3-methylpyrazine 2- (But-1 -enyl)-5-methylpyrazine... 

Ethyl 5-bromo-2-pyrazinecarboxylate 2-(2-Ethylbut-1 -enyl)-6-methylpyrazine Ethyl 5-carbamoyl-2-pyrazinecarboxylate Ethyl 5-chloro-2-pyrazinecarboxylate Ethyl 3-cyano-5,6-dimethyl-2-pyrazinecarboximidate Ethyl 3-cyano-5,6-dimethyl-2-pyrazinecarboxylate Ethyl 3,5-diami no-6-chloro-2-pyrazi necarboximidate Ethyl 6-diethylamino-2-pyrazinecarboxylate 2-Ethyl-3,6-diisobutyl-5-methylpyrazine 2-Ethyl-3,6-diisobutylpy razi ne 2-Ethyl-3,6-diisobutylpyrazine 1 -oxide 2-Ethyl-3,6-diisobutylpyrazine 4-oxide 2-Ethyl-3,6-diisopropylpyrazine /V-Ethyl-AyV -dimethyl-3,5-bismethylamino-2,6-pyrazinedicarboxamide Ethyl 3,6-dimethyl-5-oxo-4,5-dihydro-2-pyrazinecarboxylate... 

Bromination of 23-diniethylpyrazine 1,4-dioxide in dioxane in the presence of benzoyl peroxide gave 2-(bromomethyl)-3-methyl- and 2,3-bis(bromomethyl)-pyrazine 1,4-dioxide (739), and 2-methylpyrazine 1,4-dioxide gave 2-bromo-... 

Dimethoxy-2-methoxycarbonylpyrazine boiled with phosphoryl chloride and phosphorus pentachloride gave the acid chloride, which, treated with aqueous hydrazine, gave 2-hydrazinocarbonyl-3,5-dimethoxypyrazine (881). 2-Methoxy-3-methoxycarbonyl-5-methylpyrazine with methylmagnesium iodide in ether gave 3-(l -hydroxy-r-methylethyl)-2-methoxy-5-methylpyrazine (39) (844). Thebromi-nation of 2-amino-5-bromo-3-methoxycarbonylpyrazine in 30% hydrobromic acid to 2-amino-3,5-dibromopyrazine has been described in Section V.IB (2) (807). 

These authors synthesized it together with the above isomer from 2,3-diethyl-5-methylpyrazine (0.27) which was treated by /V-bromosuccinimide. The two bromo derivatives were separated by TLC, then treated with dicyclohexylamine to give the vinyl compounds. The two alkenylpyrazines could not be separated in the coffee volatiles of arabica and robusta. The mixture was therefore treated with hydrogen bromide, the bromides analyzed by high resolution GC and their EI-MS compared with data of the bromides from 0.27. 

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